In a study published by the US National Center for Biotechnology Information NCBI, heather honey was tested for its effect on the formation of biofilms of a group of dangerous bacteria such as: Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Streptococcus pneumoniae, and Enterococcus Faecal faecalis, Clostridium difficile Enteriditis and Acinetobacter baumanii.
Tests were compared with manuka honey. at 0.25 mg/ml, where the results were amazing in favor of heather flower honey which worked to prevent and inhibit the formation of biofilms in
aureus
baumanii
coli
Enteriditis
aeruginosa
As for manuka honey, it also succeeded in preventing the formation of biofilms in
faecalis
pneumoniae
Enteriditis
aeruginosa
baumanii
Molecular docking was performed using Autodock Vina to calculate the predictive binding affinities and bonding efficiencies of the Manuka honey and Heather components of PaDsbA1, the key enzyme that controls the correct folding of virulence proteins in Pseudomonas aeruginosa. A number of components, including benzoic acid and methylglyoxal, which are present in heather and manuka honey, showed a high efficacy, reduction in M formation, to the extent of the bonds to the target enzyme. This helps in the aeruginosa biofilm, which is observed in such types of honey.
Link to the full study:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7765399
